Biotage Flash 75 Radial Compression

Preparative and analytical capabilities

The preparative and analytical capabilities section of the facility comprises a variety of bench-top analytical equipment (GC and HPLC), rotary evaporators and bench and pilot scale preparative chromatography systems.

Biotage Flash 75 Radial Compression

The 6-channel Biotage Flash 75 system is a rig-mounted unit housed in the walk-in fume hood in the Secondary Processing Laboratory of the BEACON Pilot Plant Facility at IBERS Gogerddan, Aberystwyth.

Technology summary:

The key features are:

  • Six channel for multiple simultaneous purification runs.
  • Radially-compressed 75mm id barrels squeeze the cartridge walls to give increased efficiency by improving bed density and minimizing the chance of voiding and channeling.
  • Up to 100psi working pressure.
  • ~ 75% faster than glass columns.
  • 250ml/min flow rates
  • Reliable Gram-scale Purification: different cartridge sizes enable purification from tens of grams to hundreds of grams of crude reaction mixture.
  • Choice of 200g, 400g or 800g cartridges.
  • Flash 75 cartridges provide a direct scale-up pathway from smaller scale Biotage flash cartridges.
  • Wide range of interactive and adsorptive chromatographic media available in Flash 75 cartridge format.
  • Evaporative light scattering detector available for peak detection of non-chromophoric compounds.